Much against his will, Aurélien Brada is put in charge of a cute orphan girl and her cute dog.
Amanda Weber is a museum employee. Her nephew, Victorien, who feels that wild animals should not be kept in zoos, while hitchhiking saw a mysterious bus with 50 dead tourists that later was found by autorities at the bottom of a lake. When Victorien gets in very serious problems due to what he saw Amanda seeks to find out what happened and soon also becomes a target.
The insane Doctor Enger is obsessed with his plan to build a hospital to cure blind children, and goes on a killing and kidnapping spree with the police in pursuit.
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